ABSTRACT
Background: Human papillomaviruses [HPVs] are the most common viruses which can be sexually transmitted. They can cause different malignancies in asymptomatic women. The association of HPVs with infertility among men and women is controversial. In the current study, the authors compared the frequency of HPVs in fertile and infertile women in the city of Mashhad
Materials and Methods: In the present case-control study, cervical and vaginal smears were collected from infertile and fertile women. HPVs were detected by polymerase chain reaction. Data was analyzed by SPSS v.20 and P-value <0.05 was considered statistically significant
Results: In the current study, 115 infertile women with the mean age of 30.5 +/- 5.6 years and 60 fertile women with the mean age of 32.6 +/- 9.3 years were included [p=0.07]. Among women who were infertile [cases], 121 [52.6%] of 230 smears were positive, while in control group [who were fertile], 50 [41.7%] of 120 smears were positive [p=0.052]
Conclusion: Frequency of HPV in both groups was high, which could be due to lack of routine HPV vaccination. HPV can cause placenta abnormality, our infertile women had multiple abortion history and history of abortion had significant differences among infertile and control group. The frequency of HPV had no significant differences between the infertile and control groups
ABSTRACT
Background: Recurrent miscarriage is defined as two or more recurrent spontaneous miscarriages. Several causes have been suggested, among which, chromosomal abnormalities in couples is considered to have a role in this regard. However, its significance varies among different populations. The present study was carried out to evaluate the prevalence of chromosomal aberrations in couples with recurrent miscarriages in the city of Mashhad
Materials and Methods: A retrospective study was performed on patient records at Medical Genetics Clinic of Imam Reza hospital in Mashhad [north-east of Iran] between 2003 and 2006
Results: Of 151 records of recurrent miscarriages, 59 couples had undergone Karyotyping testing. Among those who had Karyotyping results, only one [1.7%] had chromosomal abnormality. The observed abnormality was associated with chromosome 9 inversion. The prevalence of consanguineous marriage among these couples was 59.0%
Conclusion: In our study, unlike similar studies in other countries, the prevalence of chromosomal abnormalities was much lower. This could be interpreted either due to laboratory errors in our clinic or the real reduction in the association of chromosomal abnormalities with recurrent miscarriages in our population. Regarding our data, it seems that, at least among our population, costly Karyotyping testing is not necessary to predict further miscarriages or it could be limited to fewer cases having other associated factors